What Spanish Ports used during XVI?

There are three ports in Spain that were there during XVI period:

Puerto San Sebastian:

http://oi60.tinypic.com/142fsp2.jpg

Puerto Santander:

http://oi57.tinypic.com/2ym9bm1.jpg

Puerto Sevilla:

http://oi58.tinypic.com/s3zkte.jpg

Included are the three pictures. Most of the spanish explorers that arrived to Zacatecas were from the Basque region from "Gipuzkoa" such as Francisco Ibarra, etc.

http://en.wikipedia.org/wiki/Gipuzkoa

The ports of San Sebastian and Santander are located in the northern side of Spain near the Basque region. So I wonder if that is where they embarked rather than Sevilla which is at the very south side of Spain.